Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Cavidine protects against asthma in neonatal asthmatic mice model by attenuating PI3Ks/NF-κB signaling pathway

Qin Hao, Juan Shen, Lin Zhao

Department of Pediatric Nursing Teaching and Research, Medical College of Yan'an University, Shaanxi 716000, China;

For correspondence:- Lin Zhao Email: VApriloelm@yahoo.com Tel:+869112412293

Accepted: 15 February 2019 Published: 31 March 2019

Citation: Hao Q, Shen J, Zhao L. Cavidine protects against asthma in neonatal asthmatic mice model by attenuating PI3Ks/NF-κB signaling pathway. Trop J Pharm Res 2019; 18(3):513-518 doi: 10.4314/tjpr.v18i3.10

© 2019 The authors.
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Abstract

Purpose: To evaluate the protective effect of cavidine against asthma in neonatal mice.

Methods: Neonatal mice were treated with cavidine at doses of 5 and 10 mg/kg, po, 2 h prior to asthma induction with ovalbumin (OVA) on the 1st and 14th days of the treatment protocol. The anti-asthma activity of cavidine was evaluated by determining the number of inflammatory cells and cytokine levels in broncho-alveolar lavage fluid (BALF) and OVA-specific IgE and TGF-β 1 in the serum of OVA-sensitized mice. The levels of NF-(9;B and PI3K protein expression were determined in the lung tissues of OVA-sensitized mice.

Results: Cavidine attenuated the number of inflammatory cells and cytokines in BALF of OVA-sensitized mice. The levels of OVA-specific IgE and TGF-β 1 decreased significantly in cavidine-treated groups, when compared to asthmatic group of mice, while NF-(9;B was significantly downregulated (p < 0.01). The altered expression of PI3K signaling protein was attenuated in the lung tissues of cavidine-treated mice sensitized with OVA.

Conclusion: These results reveal that the anti-asthma effect of cavidine in OVA-induced asthmatic neonatal mice occurs via reduction of inflammation and immune responsive cells linked to PI3Ks/ NF-κB signaling pathway in lung tissues. These findings suggest that cavidine may be clinically suitable for the management of asthma.

Keywords: Cavidine, Asthma, Inflammation, Immune cell, Neonatal, PI3K signaling